Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs
نویسندگان
چکیده
منابع مشابه
Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs
This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and excretion and potential drug-drug interactions. This overview provides an understanding of their clinical pharmacokinetics, which could assist in ...
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SUMMARY Effects on mitosis in mouse vaginal and rectal epithelium were used to screen antimitotic properties of drugs given i.p. Test drugs were given i.p. at time zero, podophyllin was injected at 2 hr, and the animals were killed at 8 hr. Both vagina and rectum were removed en bloc. Mitotic cells in the epithelia were counted histologically. The validity of the system was ascertained by testi...
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Prior to a drug achieving its effects (ie, pharmacodynamics), there are numerous events within the body that determine its ultimate fate. The effects of the "body on the drug" has been referred to as pharmacokinetics-how the favorable lung-to-systemic effects predicted from this exercise translate into practice. Inhaled drugs have enjoyed the major feature of having "local" effects on the targe...
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Skin tests are of paramount importance for the evaluation of drug hypersensitivity reactions. Drug skin tests are often not carried out because of lack of concise information on specific test concentrations. The diagnosis of drug allergy is often based on history alone, which is an unreliable indicator of true hypersensitivity.To promote and standardize reproducible skin testing with safe and n...
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Over the past 15 years, thanks to the development of clinical pharmacology, pharmacokinetics and more accurate analytical techniques, many of the variables determining the effects of drugs have been better defined and understood. We know today that the effects of most therapeutic agents are related on the one hand to the functional status of the receptors and on the other to the concentration o...
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ژورنال
عنوان ژورنال: Clinical Pharmacokinetics
سال: 2017
ISSN: 0312-5963,1179-1926
DOI: 10.1007/s40262-017-0570-0